I was Herbalism/mining, but I recently dropped Herbalism for Enchanting. After soloing a bunch of instances and dropping almost 100g on enchanting matts im up to 230 or so. Mining is almost 300. I have a couple alts that im playing around with Jewelcrafting, blacksmithing, potions, and engineering (nothing serious though).
I think the biggest money sink in the game is Jewelcrafting. To level that up you need tons of gems and rare metals. Only bonus is that its the only profession where everything is at least a green.